• Due to anatomical and physiologic characteristics of the eye

  2023-11-28

  

  Due to anatomical and physiologic characteristics of the eye, administration of ophthalmic medicines is difficult and many studies showed that only approximately 5% of the administrated dose are absorbed by intraocular tissues, making the treatment unfeasible for diseases located in posterior segmen

• Intracellular Signaling Cascades From ligand sensitization t

  2023-11-28

  

  Intracellular Signaling Cascades. From ligand sensitization to translation of genes, all cellular processes are dependent on the intracellular levels and activity of partners involved in the signaling pathway. These signaling events lead to critical post-translational modifications including phospho

• br Author Contributions br Acknowledgments br Introduction C

  2023-11-28

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to ssr distributors tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therape

• br Material and methods br Results br Discussion Aminopeptid

  2023-11-28

  

  Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors

• The beneficial treatment with several statins have been eval

  2023-11-28

  

  The beneficial treatment with several statins have been evaluated in AD patients (Kivipelto et al., 2005), with controversial results. It has been suggested that statins slow cognitive decline in mild to moderate AD (Miida et al., 2005). Treatment with atorvastatin, combined with other medications,

• br Materials and methods br Results

  2023-11-28

  

  Materials and methods Results Discussion This study demonstrates that treatment with a selective adenosine kinase inhibitor ABT-702, thereby enhancing extracellular adenosine, can provide partial protection from age-related hearing loss in C57BL/6J mice. Chronic treatment with ABT-702, comm

• br Conflict of interest br Acknowledgments

  2023-11-28

  

  Conflict of interest Acknowledgments Introduction Inflammation is a protective response of the microcirculation to harmful stimuli. Yet, excessive inflammation is potentially harmful and a characteristic of many chronic diseases [1]. 5-Lipoxygenase (5-LO, EC1.13.11.34) contributes to the in

• Steroidal CYP inhibitors can further be classified based on

  2023-11-28

  

  Steroidal CYP17 inhibitors can further be classified based on their mode of action, namely as mechanism-based inhibitors and type I and type II competitive inhibitors [129]. Recent studies investigated other biological targets than CYP17, and some new compounds have shown interesting dual activity a

• We have recently reported a regulatory effect

  2023-11-28

  

  We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the

• This study evaluated the anti

  2023-11-27

  

  This study evaluated the anti-tumor influences of LA against HepG2 sphingosine-1-phosphate in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mit

• Unfortunately results of serum plasma AC assessment after fo

  2023-11-27

  

  Unfortunately, results of serum/plasma AC assessment after food antioxidant intake are rather controversial: although some papers reported an increase of AC after food antioxidant intake (Khan et al., 2015, Torabian et al., 2009), unexpectedly, in a lot of long-term intervention studies (days, weeks

• br Eprosartan The AT R

  2023-11-27

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential e1 activating enzyme and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular e

• Some of the earliest LOX inhibitors were redox inhibitors

  2023-11-27

  

  Some of the earliest 12-LOX inhibitors were redox inhibitors, including nordihydroguaiaretic Meropenem (NDGA), BW 755C, and baicalein 48, 49, 50. Redox inhibitors block the oxidation of the nonheme iron at the cataylytic site, preventing its conversion from the inactive (Fe2+) to the active (Fe3+)

• br Preliminary remarks Expression of the transcription facto

  2023-11-27

  

  Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the Febuxostat of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental factors to an ad

• Nrf br AhR br Nrf and

  2023-11-27

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

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