• Thus synthesized thienopyrimidine derivatives were evaluated

  2021-11-05

  

  Thus synthesized thienopyrimidine derivatives were evaluated in vitro for GPR119 agonistic activity, and the results are summarized in , , . First, we fixed the 4-methylsulfonylphenyl substituent at the R position on the thienopyrimidine ring, and derivatized at the R position. As shown in , and s

• Aldicarb In the present study participants reported

  2021-11-05

  

  In the present study, participants reported a significant decrease in symptoms of anxiety and depression along with other symptoms of psychological distress and PTSD. These results are in agreement with a study in which hospitalized patients diagnosed with psychotic and mood disorders demonstrated s

• It is an aspiring task to apply

  2021-11-05

  

  It is an aspiring task to apply the glutamate biosensor for in vivo measurements in MnTBAP Chloride tissue. Due to a relatively large size of the electrode used in this work, the biosensor fits only ex vivo applications. However, it is possible to apply platinum microelectrodes 50–100 μm in diameter

• To further investigate if GPR

  2021-11-05

  

  To further investigate if GPR40 was the functional target of these phenylpropiolic Dyngo-4a analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK293-GPR40 c

• br Methods br Results br Discussion Significant alterations

  2021-11-05

  

  Methods Results Discussion Significant alterations in the expression of genes related to the glutamatergic system have been shown in several experimental models of epilepsy; however, in most studies focused on acute changes or modifications in expression, these were investigated during the

• Erythropoiesis involves the proliferation and differentiatio

  2021-11-05

  

  Erythropoiesis involves the proliferation and differentiation of hematopoietic stem L-NMMA citrate to mature RBCs. This process is a tightly-regulated to adjust rates of RBC production based on physiologic need. Fas-mediated apoptosis is one mechanism that controls erythropoiesis. The role of Fas-s

• br Methods and materials br Results br

  2021-11-05

  

  Methods and materials Results Discussion In this study we demonstrate that CF epithelial Brilliant Blue G exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible

• Compounds that induce exocytosis in cultured cells include C

  2021-11-05

  

  Compounds that induce exocytosis in cultured apelin receptor include Ca2+-dependent [14] or Ca2+-independent [15] mechanisms. Ca2+-dependent exocytosis releases soluble enzyme content from lysosomes [16] operating by increasing the cytosolic concentration of Ca2+[13] by recruiting extracellular Ca2+

• br Regulation of HO expression

  2021-11-05

  

  Regulation of HO-1 expression under conditions of ischemic cardiac damage Heart is a vital organ with high metabolic demand, rich in mitochondria and it is very vulnerable to oxidative damage [85]. Disruption in coronary blood flow following MI leads to hypoxia (a reduction in the amount of avail

• br The hedgehog signalling pathway

  2021-11-05

  

  The hedgehog signalling pathway The canonical Hh pathway is a conserved, highly complex signalling cascade, with many players and intricate regulation. However, it can be simplified into four fundamental components: i) the ligand Hh, ii) the receptor Patched (Patch [PTCH1]), iii) the signal trans

• The RAS RAF MEK ERK

  2021-11-04

  

  The RAS/RAF/MEK/ERK pathway is a central controller of cell proliferation and survival and, consequently, alterations to some of its components lead to hyperactivation of the pathway, an event related to numerous types of cancer [172]. High rates of alterations to this pathway are found in leukemia,

• The replacement of the P butyl urea cap with

  2021-11-04

  

  The replacement of the P-butyl urea cap with sulfonamide derived cap had a profound effect on binding. Compound obtained by the replacement of -butyl urea P cap of compound with sulfonamide demonstrated a =34nM, a fifteen folds improvement in potency. Similarly replacement of P-butyl cap in the P

• br cAMP cGMP effector systems

  2021-11-04

  

  cAMP/cGMP effector systems in human platelets (PKA, PKG, PDEs) In eukaryotic cells, the effects of intracellular cAMP are mediated by two types of cAMP-dependent protein kinases (PKA type I and II) and cAMP-regulated guanine nucleotide exchange factors (EPAC/cAMP-GEF) which activate the RAS GTPa

• br Lactate metabolism L Lactate

  2021-11-04

  

  Lactate metabolism L-Lactate is an intermediate metabolite in glucose metabolism. Glucose can be broken down to pyruvate, and pyruvate can be either further oxidized to acetyl-CoA and enter the TCA cycle, or reduced to L-lactate by lactate dehydrogenase (LDH). In turn, LDH can oxidize L-lactate t

• s7694 br Conclusion br Experimental procedures br Introducti

  2021-11-04

  

  Conclusion Experimental procedures Introduction The glycine receptor (GlyR) is a member of the Cys-loop family of ligand-gated ion channels. It is the primary inhibitory receptor in the brainstem and spinal cord but also plays important roles in higher s7694 regions, including the hippocamp

14929 records 550/996 page Previous Next First page 上5页 546547548549550 下5页 Last page