• Although HK localizes mainly to either the cytosol or mitoch

  2021-12-17

  

  Although HK localizes mainly to either the cytosol or mitochondria [29], [30], [31] and cardioprotection is associated with increased mitochondrial HK binding, some studies have identified a component of HK located in intracellular vesicles within the cardiomyocyte [48], [61], supporting older data

• Routine administration of exogenous GC is pertinent during l

  2021-12-17

  

  Routine administration of exogenous GC is pertinent during late gestation, particularly in women who are at risk of delivering a preterm infant, aiming at ensuring proper neonatal outcome and survival (Kamath-Rayne et al., 2012). Unfortunately, despite its beneficial roles in foetal survival, variou

• Lactate LA the end product of aerobic

  2021-12-17

  

  Lactate (LA), the end product of aerobic glycolysis, has been long neglected and seen as a byproduct until recently the findings for its important role in global gene transcription, cancer progression, functional polarisation of immune b-Casomorphin (1-3) and the sustenance of stem cells [[7], [8],

• In spite of the similarities of

  2021-12-17

  

  In spite of the similarities of caffeine's effects in L929 cells and erythrocytes, a major difference can be identified in the magnitude of inhibition (35% versus 90%). It initially seems reasonable to conclude from this finding that the reduced magnitude of caffeine inhibition in L929 cells is simp

• br FGF FGFR pathway as predictive

  2021-12-16

  

  FGF/FGFR pathway as predictive factor Several studies have identified FGFR1 amplification as the major predictive factor of response to FGFR inhibitors [26], [27]. However, in a recent study on lung cancer cell lines with ponatinib, FGFR1 mRNA and protein expression, together with FGF2 and FGF9 m

• At the heart of ferroptosis is a

  2021-12-16

  

  At the heart of ferroptosis is a process of lethal lipid peroxidation, which is the oxidative addition of molecular oxygen (O2) to lipids, such as polyunsaturated fatty acyl tails in phospholipids. The first descriptions of such enzymatic reactions were in 1955 by Peterson and colleagues [50] and Ro

• br Statistical analysis The mean standard deviation median

  2021-12-16

  

  Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t

• br Acknowledgments This research was

  2021-12-16

  

  Acknowledgments This research was funded by generous grants from the Singapore National Medical Research Council (NMRC CBRG grant NMRC/CBRG12Nov114 (BD)). WJC is supported by NMRC Clinician Scientist Investigator award and partly supported by a Singapore Cancer Syndicate Grant, the National Resea

• Beckman Coulter s DxN VERIS Molecular

  2021-12-16

  

  Beckman Coulter’s DxN VERIS Molecular Diagnostics System (DxN VERIS System) is a fully automated system for the quantitative analysis of molecular targets, integrating sample introduction, nucleic L-Phenylephrine extraction, reaction set-up, real-time PCR amplification and detection using TaqMan® ch

• The first described synthetic FFA active agonist GW

  2021-12-16

  

  The first described synthetic FFA1 active agonist, GW9508 (4- [(3-phenoxyphenyl)methyl]amino benzenepropanoic acid), was immediately shown to also activate FFA4, although with some 100-fold lower potency [38]. Therefore, in the initial absence of FFA4-selective synthetic agonist ligands, GW9508 was

• In this review we aim to provide a comprehensive

  2021-12-16

  

  In this review, we aim to provide a comprehensive understanding of: 1) how AT-resident CD4+ T cell subpopulations regulate the metabolic status of AT; and 2) how adipocytes as antigen presenting cells to modulate the activities of CD4+ T cell subpopulations in AT. Under condition with obesity, ad

• The results of our study

  2021-12-16

  

  The results of our study indicate the general importance of the gp120 V3 loop ic losartan potassium australia patch in the subunit association of primate immunodeficiency virus Env trimers. Our observation that the stem insertion mutants and hydrophobic patch mutants exhibit similar phenotypes with

• Cichlasoma dimerus as most teleost fish species present

  2021-12-16

  

  Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most GANT61 species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and the POA (González-Ma

• Estrus expression after removal of P insert and before

  2021-12-16

  

  Estrus hedgehog pathway after removal of P4 insert and before TAI is a clear predictor of greater P/AI in protocols that use GnRH [6,8], EB, or ECP [10,18] as ovulation inducers. Therefore, our third hypothesis was that heifers showing estrus behavior would have greater P/AI, which was supported in

• Introduction The hypoglossal nucleus is the nucleus of the

  2021-12-16

  

  Introduction The hypoglossal nucleus is the nucleus of the twelfth cranial nerve and is located on both sides of the mid line in the dorsal medulla oblongata and is situated between the proximal end of the medullary central canal and the beginning of the fourth ventricle (Tomasch and Etemadi, 1962)

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