• Transcriptional mapping of the SYNE gene focusing on the

  2020-07-28

  

  Transcriptional mapping of the SYNE1 gene, focusing on the CPG2 region, is a first step towards clarifying which of its transcripts and protein products are likely to play a role in BD. Identification of a full-length CPG2 transcript expressed in human brain encoding a protein that is functionally c

• Oliveira et al obtained useful

  2020-07-28

  

  Oliveira et al. obtained useful experimental data on the vapor-liquid equilibrium (VLE) of glycerol – alcohol binary systems, while they applied the CPA equation of state to describe such data [12]. Also, the CPA model was applied to describe the VLE of water – glycerol binary and the liquid-liquid

• The Pacific cup oyster genus Saccostrea has been used

  2020-07-28

  

  The Pacific cup oyster, genus Saccostrea, has been used in Australia and Asia as a sentinel bivalve for pollution monitoring, particularly of metals (Barua et al., 2011, Thompson et al., 2011, Thompson et al., 2012a, Thompson et al., 2012b, Andrew-Priestley et al., 2012, Taylor et al., 2013, Taylor

• The Fontan circulation When first described in the

  2020-07-28

  

  The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital TH287 disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a total cavopulm

• br Materials and methods br Results

  2020-07-27

  

  Materials and methods Results Discussion The role of pro-inflammatory pathways linked to the ubiquitin-proteasome system in the pathogenesis of atherosclerosis is an emerging area of investigation. Indeed, studies demonstrate putative roles of proteasomal blockade, protective effects of ubi

• 1400w There are at least and E Ub

  2020-07-27

  

  There are at least 37 and 48 E2 Ub-conjugating 1400w in Arabidopsis and rice, respectively [23]. Although the U-box proteins have to interact with E2s for their E3 ligase activities and there are large numbers of U-box E3s in plant genomes, studies of the U-box structure or E2-binding requirements

• Investigations of CaM structures in complexes with different

  2020-07-27

  

  Investigations of CaM structures in complexes with different target peptides have highlighted the different modes of binding that illustrate the remarkable plasticity of CaM [10], [16], [17], [18], [19]. The selective Ca2+–CaM dependent-target regulation is likely to be due to the order of associati

• The term myeloproliferative disorders was first proposed by

  2020-07-27

  

  The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myeloproliferative dis

• In this study we determined the

  2020-07-27

  

  In this study, we determined the regulatory role of CysLT2R in microglial inflammation and subsequent neurotoxicity in an in vitro lipopolysaccharide (LPS)-induced inflammation model of PD (Chinta et al., 2013, Hosoi et al., 2014, Svensson et al., 2010). In addition, we also examined the neuroprotec

• Our study demonstrated that atipamezole strongly inhibits th

  2020-07-27

  

  Our study demonstrated that atipamezole strongly inhibits the seven-major human CYP isoforms including CYP2C9 (diclofenac 4′-hydroxylation) in HLM, as well as in DLM and RLM. No IC50 shift toward left side was observed indicating the inhibitory effect was in a reversible manner. On the other hand, t

• br Conclusion and future perspectives br

  2020-07-27

  

  Conclusion and future perspectives Conflict of interest Acknowledgments This work was supported in part by grants from the National Institutes of Health (CA49639, 100632, CA136411, and CA16672), the Paul and Mary Haas Chair in Genetics (all to M.A.), and the Japan Society for the Promotion

• Overall our results show that rats

  2020-07-27

  

  Overall, our results show that rats exhibited heightened anxiety-like behaviors both 24h and 2 weeks following the last repeated injection of amphetamine. The distance traveled in the EPM was nearly identical between saline- and amphetamine-treated groups at both time points measured, suggesting tha

• 2-Deoxyadenosine 5-diphosphate Carbon dioxide is the gas mos

  2020-07-27

  

  Carbon dioxide is the gas most commonly applied for supercritical fluid extraction due to its low cost, high purity, safety and low critical properties. Since pure supercritical carbon dioxide (scCO2) is a lipophilic solvent, mixtures with organic solvents, especially alcohols, are used to increase

• The methods of choice to assess collagen

  2020-07-27

  

  The methods of choice to assess collagen glycosylation range from the analysis of single amino acids following alkaline hydrolysis [13] up to liquid chromatography–tandem mass spectrometry (LC–MS/MS) [12,14,15]. The low complexity of the polypeptide sequence and the intermolecular/intramolecular cov

• br Limitations of the study br Possible conflicts of interes

  2020-07-25

  

  Limitations of the study Possible conflicts of interest Dr. Fayemiwo or SAF has received full financial support from Europe Gilead Sciences Ltd. for his M.Sc. degree programme in Medical Mycology and has been paid for talks on behalf of AstraZeneca and GSK. Caroline Moore or CBM has received

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