• In the present study we investigated the role of

  2020-08-10

  

  In the present study, we investigated the role of EP1R after ICH and its mechanism of action. We hypothesized that EP1R activation aggravates ICH injury but that its blockade reduces injury through the Src kinases and the MMP-9 signaling pathway. To test this hypothesis, we examined the effects of s

• In vitro studies suggest that cPLA

  2020-08-10

  

  In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24]. In this regard, mass spectrometry analyses of glycerophospholipid hydr

• There are two types of DDRs DDR and DDR

  2020-08-10

  

  There are two types of DDRs, DDR1 and DDR2, which are type I transmembrane RTKs characterized by an N-terminal extracellular discoidin domain containing a collagen binding site [8]. DDR1 expression is somewhat restricted to epithelial cells, while DDR2 is often expressed in cells of mesenchymal orig

• br Materials and methods br Results br Discussion In

  2020-08-10

  

  Materials and methods Results Discussion In rodent species, CYP2E1 and CYP2B have been implicated in CCl4 metabolism. In this study, we used expressed human CYP2E1 to show that this enzyme is a high-affinity catalyst responsible for low-dose CCl4 metabolism. Studies employing an inhibitory

• One question relates to our

  2020-08-10

  

  One question relates to our finding that oxysterol-GPR183 signaling is critical for CP and ILF formation in the colon but dispensable in the small intestine. GPR183 and its ligand were expressed in both the small and large intestines. Moreover, 7α,25-OHC was required for ILC3 migration to CPs not on

• Programmed cellular death or apoptosis

  2020-08-09

  

  Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s

• Dihydrofolate reductase DHFR is an excellent molecular

  2020-08-08

  

  Dihydrofolate reductase (DHFR) is an excellent molecular target for this study because it has been and is currently studied by using different molecular modeling techniques [6], [7], [8], [9]. Kerrigan et al. have reported an interesting review about recent progress in molecular dynamics simulations

• Our data show a site specific interaction of

  2020-08-08

  

  Our data show a site-specific interaction of DDR2 with collagen II. This indicates that the DDRs recognise a particular sequence within collagen and not simply the collagenous triple helix per se. This common tertiary structure of all collagens is formed by three α chains, each with a repeating G-X-

• In terms of downstream kinases in the

  2020-08-08

  

  In terms of downstream kinases in the MAPK pathway, MEK mutations have been mainly identified in melanoma, and also in ovarian cancer cell lines and gliomas34, 35. Generally, all of the upstream mutations can lead to ERK protein hyperactivation, which is responsible for a series of ERK-signaling-reg

• Hinokitiol possesses potent anti tumor effects

  2020-08-08

  

  Hinokitiol possesses potent anti-tumor effects by inducing cell apoptosis (Seo et al., 2017). Our present study also demonstrated that hinokitiol induced apoptosis effects (Fig. 1A, D) possibly through suppression of survivin expression in melanoma B16-F10 Eptifibatide receptor (Fig. 2). Increased

• Biochemical characterization of SjCE b

  2020-08-08

  

  Biochemical characterization of SjCE-2b has not been reported due to the insolubility and denatured conformation of the recombinant molecule in bacteria-expressed T-5224 which failed to display its enzymic activity. Recovery of refolded bioactive protein possessing native conformation enabled us to

• br Phenotypic responses alkylation induced cell death and mu

  2020-08-06

  

  Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla

• Patients with PP have been reported

  2020-08-06

  

  Patients with PP have been reported to have higher rates of autoimmune thyroiditis and pre-eclampsia, both of which have an immunological basis (Bergink et al., 2011, 2015). Various autoimmune diseases like rheumatoid arthritis (RA), multiple sclerosis (MS) and autoimmune thyroiditis frequently remi

• Successful antiparasitic vaccines often contain several anti

  2020-08-06

  

  Successful antiparasitic vaccines often contain several Telbivudine combined with adjuvants [2]. In this context surface proteins from parasites have mainly been investigated as potent antigens but recent work suggests that enzymes such as proteases may be potent targets as well. Cysteine proteases

• We have observed that MTX

  2020-08-06

  

  We have observed that MTX boosted intracellular ROS generation in cultured HepG2 cells. Previous reports have revealed that oxidative damage caused by the ROS generation is the major cause of MTX tissue injury (Yiang et al., 2014; Hafez et al., 2015). In the cells which were pretreated with TAT-CPG2

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