• br Regulation of DGK activity Activation of the DGKs

  2020-07-29

  

  Regulation of DGK activity Activation of the DGKs is complex and unique for each DGK isotype. In most cases, DGKs must translocate to a membrane compartment to access DAG. However, translocation does not necessarily activate the enzyme [57]. In addition, DGK activity can be modified by other cofa

• The number substrate specificity and Ca dependence of altern

  2020-07-29

  

  The number, substrate specificity, and Ca2+ dependence of alternative NAD(P)H dehydrogenases vary significantly when different organisms are compared. For instance, Arabidopsis mitochondria may possess up to seven proteins, including three external dehydrogenases: two are NADH dehydrogenases, one of

• Transduction of cellular signals by G protein coupled recept

  2020-07-29

  

  Transduction of cellular signals by G protein-coupled receptors (GPCRs) is stringently regulated to prevent the deleterious effects of unrestrained GPCR signaling. The rapid termination of signaling mediated by agonist-occupied GPCRs is referred to as homologous desensitization and involves the foll

• Specific agonists of both dopamine

  2020-07-28

  

  Specific agonists of both dopamine receptors impact their heterodimerization. The value of the energy transfer between the dopamine D1 and the natural D2 receptors is higher when the amd3100 are concurrently stimulated with chloro-APB and quinpirole – two specific ligands of dopamine D1 and D2 rece

• br Results br Discussion We

  2020-07-28

  

  Results Discussion We used ATP acyl phosphates and quantitative LC-MS to map ligand binding regions corresponding to the active site of mammalian DGKs. We defined, for the first time, the location of the ATP binding site of representative isoforms from all five principal DGK subtypes (Figure 5

• Incorporation of C http www

  2020-07-28

  

  Incorporation of [14C] oleoyl into TAG was 72–89% for R. communis or E. lathyris and 37–54% for E. lagascae. For E. lagascae VIR E and E. lagascae VIR R or E. lathyris ELAT R, image analysis gave null counts mm−2, but scintillation counter recorded 26, 64 or 82.9 CPM. In this case, we included the

• Sixty eight male Sprague Dawley rats were acquired from the

  2020-07-28

  

  Sixty-eight male Sprague–Dawley rats were acquired from the University of South Dakota Laboratory Animal Services (Vermillion, SD, USA) and housed in pairs at 22°C (60% relative humidity) on reverse 12h light/dark lysophosphatidic acid (dark cycle started at 10:00a.m.) with food and water freely ac

• br Material and methods br Results br

  2020-07-28

  

  Material and methods Results Discussion This study was performed to investigate the molecular correlates of addiction in a model based on the development of psychomotor sensitization which takes place after repeated nicotine administrations (Carboni et al., 2016; Vezina et al., 2007; Zivian

• Transcriptional mapping of the SYNE gene focusing on the

  2020-07-28

  

  Transcriptional mapping of the SYNE1 gene, focusing on the CPG2 region, is a first step towards clarifying which of its transcripts and protein products are likely to play a role in BD. Identification of a full-length CPG2 transcript expressed in human brain encoding a protein that is functionally c

• Oliveira et al obtained useful

  2020-07-28

  

  Oliveira et al. obtained useful experimental data on the vapor-liquid equilibrium (VLE) of glycerol – alcohol binary systems, while they applied the CPA equation of state to describe such data [12]. Also, the CPA model was applied to describe the VLE of water – glycerol binary and the liquid-liquid

• The Pacific cup oyster genus Saccostrea has been used

  2020-07-28

  

  The Pacific cup oyster, genus Saccostrea, has been used in Australia and Asia as a sentinel bivalve for pollution monitoring, particularly of metals (Barua et al., 2011, Thompson et al., 2011, Thompson et al., 2012a, Thompson et al., 2012b, Andrew-Priestley et al., 2012, Taylor et al., 2013, Taylor

• The Fontan circulation When first described in the

  2020-07-28

  

  The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital TH287 disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a total cavopulm

• br Materials and methods br Results

  2020-07-27

  

  Materials and methods Results Discussion The role of pro-inflammatory pathways linked to the ubiquitin-proteasome system in the pathogenesis of atherosclerosis is an emerging area of investigation. Indeed, studies demonstrate putative roles of proteasomal blockade, protective effects of ubi

• 1400w There are at least and E Ub

  2020-07-27

  

  There are at least 37 and 48 E2 Ub-conjugating 1400w in Arabidopsis and rice, respectively [23]. Although the U-box proteins have to interact with E2s for their E3 ligase activities and there are large numbers of U-box E3s in plant genomes, studies of the U-box structure or E2-binding requirements

• Investigations of CaM structures in complexes with different

  2020-07-27

  

  Investigations of CaM structures in complexes with different target peptides have highlighted the different modes of binding that illustrate the remarkable plasticity of CaM [10], [16], [17], [18], [19]. The selective Ca2+–CaM dependent-target regulation is likely to be due to the order of associati

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