• br Structure of ketosteroid dehydrogenase Overall fold High

  2019-09-23

  

  Structure of 3-ketosteroid Δ1-dehydrogenase Overall fold — High-resolution crystal structures of Δ1-KSTD are currently available for the Δ1-KSTD1 isoenzyme from R. erythropolis SQ1 [30]. The Δ1-KSTD1 molecule has an elongated shape, and consists of two domains, an FAD-binding domain and a catalyt

• The second DDR binding partner identified here Shp

  2019-09-23

  

  The second DDR1-binding partner identified here, Shp-2, which was not found in the two-hybrid screen but using a bioinformatics approach, is also a mediator of cell migration. Since Shp-2 has two SH2 domains, as well as phosphotyrosine phosphatase enzymatic activity and two C-terminal tyrosines targ

• Western blotting Western blotting was performed

  2019-09-23

  

  Western blotting: Western blotting was performed following the standard protocol as previously described [16]. All the images were collected using the Odyssey Fc imaging system (Li-COR Biosciences). In vitro kinase assays were performed on ∼1 μg of purified CDK5/p35 complex in 30 μL of kinase buffe

• Under conditions of energy scarcity or nutritional restricti

  2019-09-23

  

  Under conditions of energy scarcity or nutritional restriction, AMPK, a critical energy sensor, is activated in response to the increased ratio of AMP to ATP. Various kinases may phosphorylate AMPK, leading to its activation. For example, AMPK phosphorylation by liver kinase B 1 (LKB1) at Thr172 res

• In the original ELF study patients were considered eligible

  2019-09-23

  

  In the original ELF study [7], patients were considered eligible if they were due to undergo liver biopsy for the investigation of chronic liver disease, defined as abnormal biochemical liver function tests persisting for more than 6 months, ability to provide informed consent and age between 18 and

• Exogenous administration of POCs could theoretically inhibit

  2019-09-23

  

  Exogenous administration of POCs could theoretically inhibit breastfeeding [69]; however, the evidence in this review does not generally support a negative impact on breastfeeding outcomes. Studies examining the CYC202 of POCs among postpartum women overall demonstrated no adverse effects on measure

• The most common pathology associated with FGR is

  2019-09-23

  

  The most common pathology associated with FGR is poor placental perfusion as a result of abnormal placentation [4]. Placental developmental disorders and insufficient hormone synthesis may lead to FGR [5,6]. However, the exact mechanism responsible for abnormal placental development remains unclear.

• The glycolytic pathway is a

  2019-09-23

  

  The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO

• The HEV vaccine developed based on p particles is

  2019-09-23

  

  The HEV vaccine, developed based on p239 particles, is of good efficacy, immunogenicity and safety, and was licensed in China in 2012. p239 (aa 368–606) and E2 (aa 394–606) share a common region of ORF2, referred to as E2s (aa 459–606), which harbors the major antigenic determinants of the HEV vacci

• Moreover a ligand for fusin

  2019-09-21

  

  Moreover, a ligand for fusin has recently been found: the lymphocyte chemoattractant stromal-derived factor-1 (SDF-1) binds to CHO those transfected with fusin and promotes secondary messenger production (Bleul et al., 1996; Oberlin et al., 1996). A new name, CXCR-4, has been proposed for the recep

• According to these results the power GaN seems more robust

  2019-09-21

  

  According to these results, the power GaN seems more robust than existing technologies (VDMOS, Superjunction, IGBT,) [5,10] and [11]. Comparing with the SiC technology, the previous works show a low SEE tolerance [[12], [13], [14]] and [15]. The SOA of power GaN devices can be equivalent to the IGBT

• br Experimental protocols br Acknowledgements This research

  2019-09-21

  

  Experimental protocols Acknowledgements This research was funded by the Croatian Ministry of Science, Education and Sports (Programmes 098-0982915-2948 and 098-0982522-2525), the Austrian Science Fund FWF (DK-MCD W1226, SFB LIPOTOX F30, P22832), and the Croatian-Austrian Intergovernmental S&T

• In some of our studies we examined the occurrence of

  2019-09-21

  

  In some of our studies we examined the occurrence of ERβ and SHBG and a possible colocalization between them. Fig. 5 shows that there is no big difference in the occurence of ERβ after short time (A) as well as long time (B) treatment with E2. We can find the receptor at the cell membrane as well as

• The objective of the present work is

  2019-09-21

  

  The objective of the present work is to search for the optimum blend when 12.5–50% metakaolin is substituted by RHA and reacted with 10 M sodium hydroxide solution to produce geopolymers. It was hypothesized that the amorphous find out this here from RHA will increase the Si/Al ratio of the mix and

• br Methods br Results and discussion

  2019-09-21

  

  Methods Results and discussion Conclusions Conflict of interest Acknowledgment The research is supported by the National Natural Science Foundation of China (Grant No. U1603285). Overview of the MAPK pathway The mitogen-activated protein kinases (MAPK) pathway, often known as a ca

15218 records 988/1015 page Previous Next First page 上5页 986987988989990 下5页 Last page